Introduction
The Brain Sterol Atlas is a data visualizer for sterol lipids in different brain regions in the aging mouse. The data in the Brain Sterol Atlas is associated with our recent publication, which ten brain regions from mice at the ages of 6 and 68 weeks were analyzed using an ion mobility-mass spectrometry (IM-MS) based four-dimensional sterolomics technology.
The Brain Sterol Atlas allows for exploring the quantitative levels of different sterol lipids across ten brain regions categorized by the sterol family and the cluster groups. The concentration of identified sterol lipids was normalized to tissue weight. For a specific data set defined by users, both interactive 2D and 3D maps of the mouse brain colored by concentrations of sterol lipids are provided. Each map is accompanied by a table detailing the information on sterol lipids and concentration values across ten different brain regions.
Publication
- T. Li, Y. Yin, Z. Zhou, J. Qiu, W. Liu, X. Zhang, K. He, Y. Cai, and Z.-J. Zhu* (corresponding author), Ion Mobility-based Sterolomics Reveals Spatially and Temporally Distinctive Sterol Lipids in Mouse Brain, Nature Communications, 2021, 12, 4343. https://doi.org/10.1038/s41467-021-24672-x